The main expected overdose complications are renal dysfunction, liver, visual disturbances (including detachment of the retina) and hearing (deafness), severe myelosuppression, uncontrollable vomiting, and / or severe neuritis. In case of overdose may be fatal.
The antidote to cisplatin is not known. Treatment is symptomatic. Partial effect can be achieved by hemodialysis conducted during the first three buy parabolan hours after the overdose.
Interaction with other medicinal products and other forms of interaction
The simultaneous or sequential application of cisplatin, aminoglycoside antibiotics (gentamicin, kanamycin, streptomycin) or with other potentially nephrotoxic drugs (eg, amphotericin B) may potentiate its nephrotoxic and ototoxic effects.
“Loop” diuretics (furosemide, clopamide, ethacrynic acid) may strengthen ototoxicity of cisplatin.
it is known that cisplatin may interfere with the excretion through the kidneys bleomycin and methotrexate (possibly due to cisplatin-induced nephrotoxicity) and enhance the toxicity of these drugs. In patients receiving cisplatin and anticonvulsants last concentration in serum may be reduced up to values subtherapeutic. Cisplatin may cause an increased concentration of uric acid in the blood. Therefore, patients who take both drugs for the treatment of gout such as allopurinol, colchicine, probenecid or sulfinpyrazone, correction may be necessary dosage of these drugs, to control attacks of gout and hyperuricaemia.
- Introduction should be carried out. under the supervision of a physician who is experienced in the use of anticancer drugs.
- Men and women of childbearing age during treatment should use reliable methods of contraception.
- Patients during buy parabolan treatment should be inspected periodically neurologist. When obvious symptoms of toxic effects on the therapy should be discontinued.
- Before starting therapy should be audiometry, and in cases where there are symptoms of the organ of hearing or hearing impairment are detected clinically, shows repeated audiometry. If clinically significant hearing impairment may require a dosage adjustment or cancellation of therapy.
- During treatment requires periodic analysis of blood, determination of the content of leukocytes, platelets, hemoglobin, blood counts, liver and renal function tests, electrolytes and blood serum.
- When using must comply with all the usual regulations adopted for the application of cytotoxic drugs.
- In case of contact with the drug in their eyes, rinse immediately with plenty of water or 0.9% sodium chloride solution. In case of contact with the drug on the skin, rinse immediately with a place of contact with plenty of water. In case of inhalation of the drug or getting it in your mouth you should immediately consult a doctor.
Valium for solution for infusion and intraperitoneal administration.
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