It plays an important role in the metabolism of histamine. Promotes normalization of lipid metabolism. The drug increases the urine output and increases the effects of diuretics. Isolated pyridoxine deficiency is very rare, especially in children who are on a special artificial diet (manifested by diarrhea, convulsions, anemia, peripheral neuropathy can develop). Pharmacokinetics:
rapidly absorbed throughout parabolan side effects the small intestine, more and more absorbed in the jejunum.
It is metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxal phosphate and piridoksaminofosfat). Pyridoxal phosphate is bound to plasma proteins by 90%. It penetrates into all tissues; It accumulates primarily in the liver, muscle and less -to the central nervous system. Penetrates through the placenta, is secreted in breast milk. The half-life of 15-20 days. Shown kidneys, as well as during hemodialysis.
Treatment of hypo-and vitamin B 6 . In the treatment of:
– diseases of the nervous system (neuralgia, Meniere’s syndrome);
– in Dermatology (dermatitis, including atopic and seborrheic: herpes zoster, neurodermatitis, psoriasis, exudative diathesis)
– sideroblastic anemia;
– acute and chronic hepatitis.
: Hypersensitivity to the components included in the composition of the drug, children’s age (for a given dosage).
The caution gastric ulcer and duodenal ulcer (in connection with a possible increase in the acidity of gastric juice), ischemic heart disease, severe liver disease.
Use during pregnancy and breast-feeding
This dosage is not recommended for use during parabolan side effects pregnancy and breastfeeding.
Dosing and Administration
Inside (after a meal)
for prophylaxis in 6 – hypovitaminosis adults -. 5 mg / day
administered medication taken after meals Therapeutic doses when administered up to adults 20-30 mg 1-2 times a day course of treatment is 1 -2 months.
When using isoniazid, ftivazida or other derivatives of isonicotinic acid hydrazide is expedient to appoint pyridoxine 5-10 mg per day prophylactically (to prevent disorders of the central nervous system).
for the treatment of sideroblastic anemia appointed interior 100 mg daily.
It is advisable to simultaneously take folic acid, cyanocobalamin, riboflavin.
Allergic reactions, gastric hyperacidity, pain epigastralnoy field, the emergence of a sense of compression in the limbs – a symptom of “stocking” and “gloves”, reduced lactation.
Interaction with other drugs
increases the effects of diuretics, decreases the activity of levodopa.
Isonicotinyl hydrazide, penicillamine, cycloserine and estrogensoderzhaschie oral contraceptives impair the effect of pyridoxine.
It is combined with cardiac glycosides (pyridoxine enhances the synthesis of contractile proteins in the myocardium), glutamic acid, and potassium and magnesium aspartate (asparkamom).
Pyridoxine prevents or reduces the toxic manifestations, including liver damage observed in the application of isoniazid and other anti-TB drugs.
The need for vitamin Wb satisfied with food as part of it is synthesized by intestinal microflora.
The daily requirement of pyridoxine for adults – 2-2 5 mg. For women – 2 mg and further in pregnancy 0 3 mg during breastfeeding -. 0 5 mg
In severe liver damage pyridoxine parabolan side effects in high doses may cause a worsening of its functions.
As part of the preparation contains glucose, to which attention should be paid to patients with diabetes mellitus .
In determining urobilinogen using Ehrlich reagent may distort the results.