There are currently no sufficient data on the use of felodipine in pregnant women. Based on these animal data on the violation of the fetus, felodipine should not be administered during pregnancy. Blockers “slow” calcium channel may inhibit uterine contractions in preterm labor, tren hexahydrobenzylcarbonate however, is not enough evidence to support an increase in the duration of physiological childbirth. Possible risk of fetal hypoxia in the presence of maternal arterial hypotension and a decrease in perfusion in the uterus due to redistribution of the blood flow and peripheral vasodilation. Lactation Felodipine passes into breast milk. When receiving a nursing mother felodipine in therapeutic doses, only a small amount of the drug gets into breast milk to the child. Lack of experience of felodipine in women during lactation does not exclude the risk of exposure to the drug on children who are breastfed, and therefore is not recommended for felodipine women during lactation. If you want to continue the therapy to achieve clinical effect should consider termination of breastfeeding.
Dosing and Administration
Inside, taken in the morning with water. The tablet does not share, do not crush or chew. The tablets can be used on an empty stomach or with a small amount of food is low in fat and carbohydrates.Hypertension The dose should be individualized. The starting dose is 5 mg once daily. The usual maintenance dose is 5 mg once daily. If necessary, the dose may be another antihypertensive agent can be added to be increased or Plendilom therapy. In elderly patients or in patients with hepatic impairment tren hexahydrobenzylcarbonate is usually sufficient dose of 2.5 mg. Rarely prescribe the drug more than 10 mg per day. Angina pectorisThe dosage should be individualized. It is necessary to begin treatment with a dose of 5 mg once a day, increasing the dose to 10 mg once a day, if necessary. It may be administered in conjunction with beta-blockers. Impaired renal function Impaired renal function did not affect the plasma concentrations of the drug. No need to adjust the treatment regimen in patients with renal impairment, however caution should be exercised when administered to patients of the drug with severe renal insufficiency (see. “Special Instructions” section). Children Experience with felodipine in children is limited.
The most frequent adverse reactions when taking Plendila include dose-dependent effect: ankles pulmonary edema – moderate severity caused by vasodilatory properties of felodipine, for this reason, approximately 2% of patients refuse to taking the drug.
At the beginning of therapy or when the dose is increased may experience redness person, accompanied by “tides”, headache, palpitations, dizziness, and weakness. Typically, these reactions are temporary and disappear on their own.
There are isolated reports of sleep disorders, but the connection with the reception of felodipine has not been established.
It has been reported cases of mucosal tren hexahydrobenzylcarbonate hyperplasia tongue and gums after administration of felodipine in patients with pronounced gingivitis / periodontitis. To avoid this side effect or reduce its symptoms is recommended thorough oral hygiene. It is believed that hyperglycemia occurs in patients receiving group blockers “slow” calcium channels, but in patients receiving felodipine hyperglycemia was observed only in individual cases.