After a single dose of 20 mg of omeprazole comes into effect during the first hour and lasts for 24 hours, the maximum effect is achieved in 2 hours. Inhibition of 50% of the maximum secretion lasts for 24 hours. A single dose per day provides a quick and effective inhibition of daytime and nocturnal gastric secretion, reaches its maximum after 4 days of treatment. In patients with peptic ulcer trenbolone hex disease 12 duodenal ulcer receiving omeprazole 20 mg maintains an intragastric pH at 3 for 17 hours. After discontinuation secretory activity is completely restored by the end of 3-4 days.
Omeprazole is rapidly absorbed from the gastrointestinal tract, peak concentration is reached in 0.5-3 hours in plasma. Bioavailability is 30-40%. If readmission bioavailability of 60-70%, depending on the dose. It increases to almost 100% When liver failure. Plasma protein binding is 95-97%. T1 / 2 is 0.5-1 hour. Almost completely metabolized in the liver. It writes mainly as metabolites kidney (70-80%) and in bile (20-30%). In chronic renal insufficiency excretion is reduced in proportion to the decrease in creatinine clearance. In elderly patients deducing decreases, bioavailability increases.
- gastric ulcer and duodenal ulcer;
- reflux esophagitis;
- erosive and ulcerative lesions of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory drugs, stress ulcers;
- erosive and ulcerative lesions of gastric and duodenal ulcers associated with Helicobacter pylori (in the complex therapy);
- Zollinger-Ellison syndrome.Contraindications
- hypersensitivity to omeprazole or other ingredients;
- children’s age (18 years);
Inside, in the morning, just before a meal or during a meal, do not chew the capsule, washed down with a little water. Duodenal ulcer in the acute phase of the disease – 1 capsule (20 mg) a day for 2-5 weeks (in resistant . cases up to 2 capsules per day) Peptic ulcer trenbolone hex in the acute phase and the erosive and ulcerative esophagitis – 1-2 capsules daily for 4-8 weeks. erosive and ulcerative lesions of the gastrointestinal tract caused by NSAIDs – 1 capsule per day . for 4-8 weeks Eradication pylori Helicobacter – using “triple therapy” for 1 week (20 mg of omeprazole, amoxicillin 1g, clarithromycin 500 mg – 2 times a day, or 20 mg omeprazole, clarithromycin 250 mg metronidazole 400 mg – 2 times a day, or 40 mg omeprazole once daily 1, 500 mg of amoxicillin and metronidazole 400 mg – 3 times a day) or “double” therapy within two weeks (20-40 mg omeprazole and 750 mg amoxycillin by 2 times a day, either omeprazole 40 mg – 1 time per day and clarithromycin 500 mg-3 times daily or amoxicillin 0.75-1.5 g – 2 times a day). anti-treatment of gastric ulcers and 12 duodenal ulcer – 1 capsule per day. anti-treatment of reflux esophagitis – 1 capsule per day for long periods (up to 6 months). Zollinger-Ellison syndrome– dose selected individually depending on the initial level of gastric secretions, typically from 60 mg per day . If necessary, increase the dose to 80 -120 mg per day, in this case, it is divided into 2-3 doses.Patients with severe hepatic dysfunction the daily dose should not exceed 20 mg.Side effect On the part of the digestive system: diarrhea or constipation, abdominal pain, nausea, flatulence; seldom – taste disturbance, transient increase of the level of “liver” enzymes, very rarely – dry mouth in patients with previous severe liver disease – disease, hepatitis (including jaundice), hepatic dysfunction. From the nervous system: in patients with severe concomitant somatic diseases – headache, dizziness, agitation, sleep disturbances, depression, in patients with previous liver disease – encephalopathy. from the musculoskeletal system: in some cases, myalgia, arthralgia, myasthenia gravis. from the hematopoietic system: in some cases – leukopenia, thrombocytopenia, agranulotsitopeniya, pancytopenia. For the skin: rare – skin rash and / or itching, in some cases – photosensitivity, multiforme ekssudatinaya erythema, alopecia. Allergic reactions: urticaria, angioneurotic edema, fever, bronchospasm, interstitial nephritis, anaphylactic shock. Other: rarely – discomfort, blurred vision, peripheral edema, increased sweating, gynaecomastia, trenbolone hex formation of gastric glandular cysts during long-term treatment (is a benign, reversible).
Overdose symptoms: blurred vision, drowsiness, irritability, headache, increased sweating, dry mouth, nausea, tachycardia, arrhythmia. Treatment: symptomatic. There is no specific antidote. Hemodialysis is not effective enough.
Interaction with other medicinal products
In connection with the increase in gastric pH, omeprazole may reduce the absorption of ampicillin, iron salts itraconazole and ketoconazole.
It may reduce the excretion and increase the concentration of diazepam, indirect anticoagulants, phenytoin, which in some cases makes it necessary to reduce the dose of these drugs.
Increases inhibitory effect on the system hematopoiesis other drugs.
at the same time, prolonged use of omeprazole 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol does not conducting a change in their concentration in the plasma.
Before treatment to rule out the presence of malignant process (especially when yaze stomach), because treatment, masking symptoms, may delay correct diagnosis.
If necessary, the appointment trenbolone hex during lactation is necessary to resolve the issue of termination of breastfeeding.
In patients with severe hepatic insufficiency daily dose should not exceed 20 mg.
Reception omeprazole together with food does not affect its efficiency.