p>Hypersensitivity to any component of the drug; severe congestive heart failure (IV class on a scale of New York Heart Association), cardiomyopathy, myocarditis, atrioventricular block II and III degree, bradycardia with a heart rate less than prolongation more than 420 ms, ventricular arrhythmia (including including atrial ventricular), pregnancy and breast-feeding, low blood potassium or magnesium, concomitant use with drugs that prolong the interval of the QT, severe renal insufficiency (creatinine trenbolone hexahydrobenzylcarbonate clearance less than 10 ml / min), children’s age (18 years), hereditary galactose deficiency, lactase deficiency, glucose-galactose malabsorption, phenylketonuria, sucrose izomaltoznaya failure, hereditary fructose failure, psychosis (in history).
Hyperplasia of the prostate, narrow-angle glaucoma, renal failure of varying severity (there is a risk of cumulation of the drug), agitation, delirium, depression of the central nervous system, exogenous psychosis (including history), a joint reception with IU-Mantin, triamterene / hydrochlorothiazide .
Dosing and Administration
Inside, after eating a small amount of liquid, preferably in the morning. The first 3 days – 1 tablet per day, then increase the dose to 2 tablets a day, with possible further increase in the dose of 1 tablet per week. The usual effective dose is from 1 to 3 tablets twice a day. The maximum daily dose – 600 mg. In case combination treatment is necessary to determine the dose individually. The last dose is recommended to take in the second half of the day no later than 16:00.
In elderly patients, particularly in patients suffering from the state of excitation and confusion, delirium and preddeliriya, require a lower dose.
Contraindicated concomitant use of amantadine and drugs that cause an increase in the interval, in particular: From the nervous system, sense organs and psyche: Common: insomnia, agitation, paranoid exogenous psychoses accompanied by visual hallucinations (in predisposed elderly patients), dizziness, blurred vision. Very rare: seizures (usually after receiving a dose greater than recommended), peripheral neuropathy, temporary loss of vision, myoclonus. cardio-vascular system: Very rare: arrhythmia, tachycardia, ventricular fibrillation, lengthening the interval QT, development or exacerbation of congestive heart failure, orthostatic hypotension. Often: marble skin syndrome in combination with swelling of the ankles and lower legs. on the part of the gastrointestinal tract: Common: nausea, dry mouth. Other: Often: . urinary retention in patients with prostatic adenoma Very rare: allergic skin reactions, fotosensebilizatsiya, leukopenia, thrombocytopenia, corneal edema, eye trenbolone hexahydrobenzylcarbonate reversible after discontinuation of the drug. Overdose
Symptoms include nausea, vomiting, irritability, tremor, ataxia, blurred vision, lethargy, depression, dysarthria, seizures, arrhythmias.
Treatment: gastric lavage, activated charcoal, symptomatic therapy.
Interaction with other drugs
– certain anti-arrhythmic class I A drugs (eg, kinidin, disopyramide, procainamide) and Class III (eg, amiodarone and sotalol)
– some antipsychotics (eg, thioridazine, chlorpromazine, pimozide);
– some tricyclic and tetracyclic antidepressants (e.g., amitriptyline);
– some antihistamines (e.g., astemizole, terfenadine);
– some macrolide antibiotics (e.g. erythromycin, clarithromycin);
– some inhibitors of gyrase (e.g. sparfloksasin)
-. antifungals group of azoles and other drugs, particularly bidupin, halofantrine, co-trimoxazole, pentamidine, cisapride and bepridil
simultaneous use of diuretics, representing a combination of triamterene / hydrochlorothiazide may increase amantadine concentrations in plasma. At simultaneous reception with other antiparkinsonian drugs (such as levodopa, bromocriptine, memantine, trihexyphenidyl), it may be necessary to lower the dose at the same time received the drug or two drugs in order to avoid undesirable consequences, in particular, psychotic reactions.
Anticholinergics, sympathomimetics and memantine: increase side effects.
Means stimulating the central nervous system (including stimulants), ethanol increases the risk of side effects.
Trenbolone hexahydrobenzylcarbonate should not be stopped suddenly as this may lead to worsening of symptoms. Patients with cardiovascular disease should be under constant medical supervision when administering. The treatment is contraindicated alcohol intake. Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.